It all depends on what u r tryin2 play...

for instance if i wanna play really heavy 'In Your Face' thrashy stuff i would turn gain all the way, and put Bass-10, Middle-0, Treble-7-10. And i usually scoop the mids when i play that...

But like i said ther r alot of other combinations so it all depends on wutever u all wanna play...