Putting any pedal before any other can change it's tone or behaviour as it can affect the impedance of the audio signal. For example, some fuzz circuits can seriously fail to produce a decent tone if placed after a wah pedal, but start to behave again if a buffer is placed between the two (there is also a myth that a stupidly long guitar lead will do the same trick).
I wish I had four arms.... Then I could play rhythm and lead at the same time.