I just bought my son a left handed guitar. I spent a few hours researching this dilemma. The conclusion I came to, from numerous articles, was that in the initial stages of learning how to play, a left handed person playing a right handed guitar, would probably find it a little easier fretting the neck, due to the dominant hand learning the more intricate aspects. As a persons skill level increases, the fretting becomes muscle memory, and the more difficult, intricate part of playing becomes the strumming and rhythm part, which is best done by the dominant hand. Now bear in mind...I am no expert by any means. I figured I would throw it out there for future contemplation. :)