A number of answers exist depending on your budget...

If you want to literally crush peoples bones with your tone then you will need a Mesa Boogie Triple Rectifier through a pair of 200 watt celestion loaded 4x12 cabs. However, this will be unplayable anywhere but a stadium as the cops will put you away for noise pollution if you try to crank the volume anywhere past 1 on the dial :D - Seriously, even at 1 on the dial you couldnt play this in your house and you would drown a drummer in a practice session at about 2 or 3 :eek:
Also, it will cost in the region of about $3500!

You can get good tone a lot cheaper too, what kind of budget are you working with? Are you looking for an amp, a stompbox, a head/cab combo or a digital processor or an amp modeller?